| Dr. Jaushieh Joseph Wu | |
| Tien, Chung-kwang | Deputy Minister of Foreign Affairs & Chancellor, Institute of Diplomacy and International Affairs (Since July 24, 2020) |
| Dr. Roy Chun Lee | Deputy Minister of Foreign Affairs (Since February 3, 2023) |
| Alexander Tah-ray Yui | Vice Minister of Foreign Affairs (Since June 23, 2021) |
| Lily L.W. Hsu | Secretary General (since July 26, 2020) |
| Catherine Y. M. Hsu | Director General, Department of International Information Services (since July, 2021) |
| Ivan Y. J. Lee | Director General, The Office of Parliamentarian Affairs (since September 2022) |
| Jeff Y. J. Liu | MOFA Spokesperson & Director General, Public Diplomacy Coordination Council (since January 2023) |
| Chih-hsin Chou | Director General, Department of Civil Service Ethics(Since January 2022) |
| Vincent Chin-Hsiang Yao | Director-General of European Affairs (Since October 2022) |
| Wallace Minn-Gan Chow | Director General, Department of East Asian and Pacific Affairs (since October 2021) |
| Anthony Chung-Yi Ho | Director-General, Department of West Asian and African Affairs (Since October 2022) |
| Florencia Miao-hung Hsie | Director General, Department of Latin American and Caribbean Affairs (Since June 23, 2021) |
| Douglas Yu-tien Hsu | Director General, Department of North American Affairs (Since July 24, 2020) |
| Jason Chien-Chen Lien | Director-General, Department of Treaty and Legal Affairs (Since July 2022) |
| Sharon S. N. Wu | Director General, Department of International Organizations (since March 2021) |
| Tom Chih-chiang Lee | Director General, Department of Protocol (since July 2021) |
| Bruce Chen-jung Hung | Director-General, Department of General Affairs (Since January 2021) |
| Li-ling Huang | Director General, Department of Personnel (since September 2021) |
| Pei-Hua Lee | Director General, Department of Budget, Accounting and Statistics (Since March 2022) |