| Dr. Jaushieh Joseph Wu | |
| Harry Ho-jen Tseng | Deputy Minister of Foreign Affairs (since July 24, 2020) |
| Tien, Chung-kwang | Deputy Minister of Foreign Affairs & Chancellor, Institute of Diplomacy and International Affairs (Since July 24, 2020) |
| Alexander Tah-ray Yui | Vice Minister of Foreign Affairs (Since June 23, 2021) |
| Lily L.W. Hsu | Secretary General (since July 26, 2020) |
| Joanne OU | MOFA Spokesperson & Director-General, Public Diplomacy Coordination Council (Since August 2019) |
| Wei-chih Yin | Director-General, Department of Civil Service Ethics (Since March 2019) |
| Remus Li-Kuo Chen | Director-General of European Affairs (Since March 2021) |
| Larry R.L. Tseng | Director General, Department of East Asian and Pacific Affairs (since September 2020) |
| Syin-yi Yang (Ali Yang) | Director-General, Department of West Asian and African Affairs (Since August 2019) |
| Douglas Yu-tien Hsu | Director General, Department of North American Affairs (Since July 24, 2020) |
| Kuang-chung Liang | Director-General, Department of Treaty and Legal Affairs (Since October 2018) |
| Florencia Miao-hung Hsie | Director General, Department of Latin American and Caribbean Affairs (Since June 23, 2021) |
| Sharon S. N. Wu | Director General, Department of International Organizations (since March 2021) |
| Tom Chih-chiang Lee | Director General, Department of Protocol (since July 2021) |
| Bruce Chen-jung Hung | Director-General, Department of General Affairs (Since January 2021) |
| Wen-yuan Lin | Director General, Department of Personnel (Since March 2018) |
| Tsai-long Wan | Director-General, Department of Budget, Accounting and Statistics (Since January 16, 2021) |
| William Heng-sheng Chuang | Director-General, Southern Taiwan Office (Since September 2019) |
| Phoebe Yeh | Director General, Bureau of Consular Affairs (Since January 2020) |